Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

Fetal growth (biometry) + umbilical artery Doppler vs fetal growth

Gestational age at birth (weeks) · women with twin pregnancies were randomised from 25 weeks

Fetal growth (biometry) + umbilical artery Doppler showed no clear difference in gestational age at birth (weeks) compared with fetal growth (moderate certainty).

1 finding from 1 review

Fetal growth (biometry) + umbilical artery Doppler vs fetal growth

Number of antenatal hospital admissions · women with twin pregnancies were randomised from 25 weeks

Fetal growth (biometry) + umbilical artery Doppler showed no clear difference in antenatal admission to hospital compared with fetal growth (high certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal hypothyroidism or elevated TSH · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal adverse effect: elevated TPO‐ab · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal adverse effect: elevated TPO‐ab compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: elevated TPO‐ab ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: elevated TPO‐ab ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: hyperthyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: hyperthyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Perinatal mortality · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in perinatal mortality compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review