Findings

What do systematic reviews say?

1,550 questions · 1,617 findings · 161 reviews · Neonatal

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No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

MS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1 [0.28, 3.63]
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 2 [0.67, 5.94]
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 3 [0.13, 70.83]
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Hypertriglyceridaemia · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.28 [0.69, 2.35]
5 studies · 399 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 261 participants
Low

MOFS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 347 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 374 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.5]
4 studies · 341 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.92 [0.61, 1.39]
5 studies · 373 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.8 [0.29, 2.16]
4 studies · 341 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

All alternative LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.17 [0.66, 2.07]
7 studies · 623 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 484 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.9 [0.66, 1.23]
9 studies · 674 participants
Very low

MOFS‐LE vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.49]
4 studies · 314 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All alternative LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.83 [0.37, 1.86]
7 studies · 602 participants
Low

MOFS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.94 [0.62, 1.42]
5 studies · 346 participants
Low

MOFS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.78 [0.29, 2.13]
4 studies · 314 participants
Low

MFS‐LE vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

MFS‐LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 5 [0.25, 99.95]
1 study · 60 participants
Low