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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

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No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… leads to higher short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (high certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… showed no clear difference in incidence of serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Long‐term hair regrowth ≥ 75% (greater than 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… leads to higher long‐term hair regrowth ≥ 75% (greater than 26 weeks of compared with placebo (high certainty).

1 finding from 1 review

Summary of findings table ‐ Oral classical immunosuppressants (prednisolone or cyclosporine) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Oral classical immunosuppressants… changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (very low certainty).

1 finding from 1 review

Some components of shared decision‐making, including clarification of values and preferences, vs control

Knowledge of all the options · women aged 38 to 71 years at average to moderate risk of breast cancer

Some components of shared decision‐making, including clarification… showed no clear difference in knowledge of all the options compared with control (low certainty).

1 finding from 1 review

Some components of shared decision‐making, including clarification of values and preferences, vs control

Mental health outcomes · women aged 38 to 71 years at average to moderate risk of breast cancer

Some components of shared decision‐making, including clarification… showed no clear difference in mental health outcomes compared with control (low certainty).

1 finding from 1 review

Some components of shared decision‐making, including clarification of values and preferences, vs control

Confidence in the decision made · women aged 38 to 71 years at average to moderate risk of breast cancer

It is very uncertain whether some components of shared decision‐making, including clarification… changes confidence in the decision made compared with control (very low certainty).

1 finding from 1 review

Studies focused only on enhanced communication, without clarification of values and preferences, vs control

Confidence in the decision made · women aged 40 to 75 years at average to moderate risk of breast cancer

Studies focused only on enhanced communication, without… showed no clear difference in confidence in the decision made compared with control (low certainty).

1 finding from 1 review

Studies focused only on enhanced communication, without clarification of values and preferences, vs control

Knowledge of all the options · women aged 40 to 75 years at average to moderate risk of breast cancer

Studies focused only on enhanced communication, without… leads to higher knowledge of all the options*** compared with control (high certainty).

1 finding from 1 review

Studies focused only on enhanced communication, without clarification of values and preferences, vs control

Mental health outcomes · women aged 40 to 75 years at average to moderate risk of breast cancer

Studies focused only on enhanced communication, without… showed no clear difference in mental health outcomes compared with control (high certainty).

1 finding from 1 review