Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Paracetamol vs indomethacin

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).

1 finding from 1 review

Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine)

Illicit opioid use · pharmaceutical opioid dependent people

Full opioid agonists showed no clear difference in illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (moderate certainty).

3 findings from 1 review

Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine)

Retention [ · pharmaceutical opioid dependent people

Full opioid agonists may leads to higher retention compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).

1 finding from 1 review

Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine)

Adverse effects · pharmaceutical opioid dependent people

Full opioid agonists showed no clear difference in adverse effects compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).

1 finding from 1 review

Antihistamines vs antiemetics

Proportion of susceptible participants who did not experience any motion sickness symptoms under experimental conditions Assessed by: calculated based on head movements tolerated (rotating chair); MSAQ · patients with motion sickness
1 finding from 1 review

Antihistamines vs antiemetics

Proportion of susceptible participants who experienced a reduction or resolution of existing motion sickness symptoms · patients with motion sickness

The review found no eligible studies for this question.

1 finding from 1 review

Antihistamines vs antiemetics

Physiological measures: heart rate and core temperature · patients with motion sickness

The review found no eligible studies for this question.

1 finding from 1 review

Antihistamines vs antiemetics

Adverse effects: impaired cognition and blurred vision · patients with motion sickness

The review found no eligible studies for this question.

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Utilization—at 6 months postabortion · women who experienced abortions and requested a reversible contraceptive method

Immediate may leads to higher utilization—at 6 months postabortion compared with delayed postabortion insertion of contraceptive implants (low certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Unintended pregnancy · women who experienced abortions and requested a reversible contraceptive method

Immediate probably leads to lower unintended pregnancy—at 6 months postabortion compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Rate of initiation of contraceptive implants—following medical abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate probably leads to higher rate of initiation of contraceptive implants—following medical… compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Rate of initiation of contraceptive implants—following surgical abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate may leads to higher rate of initiation of contraceptive implants—following surgical… compared with delayed postabortion insertion of contraceptive implants (low certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Failure rate of medical abortion—overall failure rate at · women who experienced abortions and requested a reversible contraceptive method

Immediate showed no clear difference in failure rate of medical abortion—overall failure rate at compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Failure rate of medical abortion—require extra medication for complete abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate showed no clear difference in failure rate of medical abortion—require extra medication for… compared with delayed postabortion insertion of contraceptive implants (low certainty).

1 finding from 1 review