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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

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No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): radiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term mortality (time‐to‐event outcome): radiotherapy versus… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Duodenum‐preserving pancreatic resection vs pancreaticoduodenectomy

Long‐term mortality · people requiring surgery for chronic pancreatitis

It is very uncertain whether duodenum‐preserving pancreatic resection changes long‐term mortality compared with pancreaticoduodenectomy (very low certainty).

1 finding from 1 review

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

All‐cause long‐term mortality · people with unexplained recurrent syncope

It is very uncertain whether summary of findings for the main comparison. Implantable loop recorder changes all‐cause long‐term mortality compared with conventional diagnostic workup (very low certainty).

1 finding from 1 review

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants healed ‐ long term (over 24 weeks) · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants healed ‐ long term (over 24 weeks) compared with any other dressing regimen (low certainty).

1 finding from 1 review

Fractional laser vs combined chemical peeling plus needling

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether fractional laser changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs fusion

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis

It is very uncertain whether SUMMARY OF FINDINGS FOR DECOMPRESSION changes pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with FUSION (very low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR FUSION vs INTERSPINOUS SPACERS

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR FUSION showed no clear difference in pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with INTERSPINOUS SPACERS (low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR FUSION vs INTERSPINOUS SPACERS

Disability Long‐term (≥ 12 months) Disability scores converted to 0 to 100 scale to allow for comparison of different disability scales (RMDQ, ODI, JOA) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR FUSION may leads to higher disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with INTERSPINOUS SPACERS (low certainty).

1 finding from 1 review