Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose delay) ( · adjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose delay) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Disease-free survival · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in disease‐free survival ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Pathological complete response · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in pathological complete response (no invasive cancer in breast or… compared with anthracyclines followed by taxane (high certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Grade 3 to 4 neutropenia · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in adverse events: neutropenia (grade 3/4) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Adverse events: neurotoxicity (grade 3/4) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in adverse events: neurotoxicity (grade 3/4) ( compared with anthracyclines followed by taxane (low certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose reduction) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose reduction) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Overall survival (survival until death from all causes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in overall survival (survival until death from all causes) compared with laparotomy (moderate certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Serious adverse events (range of outcomes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in serious adverse events (range of outcomes) compared with laparotomy (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Relapse, progression or death (calculated instead of PFS) · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP probably leads to lower progression, relapse or death compared with chemotherapy including ABVD (moderate certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: treatment‐related mortality · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP showed no clear difference in adverse event: treatment‐related mortality compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: secondary malignancies · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP showed no clear difference in adverse event: secondary malignancies compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: secondary malignancies: AML or MDS · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP may leads to higher adverse event: secondary malignancies: AML or MDS compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: infertility (secondary amenorrhoea) · Patients with early unfavourable or advanced stage HL

It is very uncertain whether escalated BEACOPP changes adverse event: infertility (secondary amenorrhoea) compared with chemotherapy including ABVD (very low certainty).

1 finding from 1 review