Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,615 questions · 1,673 findings · 190 reviews · Headline outcomes only

No studies found 278 · 16.6%GRADE not reported 85 · 5.1%Very low 328 · 19.6%Low 460 · 27.5%Moderate 402 · 24%High 120 · 7.2%

Intervention not reported

Pain (0 to 40: no pain) · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes pain (0 to 40: no pain) (very low certainty).

1 finding from 1 review

Intervention not reported

Wound complications including superficial/deep wound infection and osteomyelitis 1 year · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes wound complications including superficial/deep wound infection and… (very low certainty).

1 finding from 1 review

Intervention not reported

Fracture union 1 year · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes fracture union 1 year (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

VISA‐A (score 0 to 100; 100 = no problems) After 3 months (6 to 12 months) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

Summary of findings: Injection therapies showed no clear difference in VISA‐A (score 0 to 100; 100 = no problems) At 6 weeks compared with placebo or no injection control (low certainty).

3 findings from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Adverse events At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes adverse events At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Pain (VAS; score 0 to 100; 0 = no pain) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes pain (VAS; score 0 to 100; 0 = no pain) compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Return to sports At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes return to sports At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Patient satisfaction Number of satisfied patients · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes patient satisfaction (number of participants satisfied with their… compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence in trials using vitamin D₃ (cholecalciferol) · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence in trials using vitamin D₃ (cholecalciferol) compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to lower cancer mortality in trials using vitamin D₃(cholecalciferol) compared with placebo or no intervention (low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Adverse events ‐ Nephrolithiasis in trials using vitamin D3 combined with calcium · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to higher adverse events: nephrolithiasis in trials using vitamin… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐response at post‐treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes clinical non‐response at post‐treatment compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐response at · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes clinical non‐response at compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Acceptability (number of participants lost to post‐treatment assessment) · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at post‐treatment Dropout rates compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Secondary outcome: acceptability of treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐remission at post‐treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes non‐remission at post‐treatment compared with other psychological therapies (very low certainty).

1 finding from 1 review