What do systematic reviews say?

Polymyxins vs aminoglycosides

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Polymyxins vs aminoglycosides

The review found no eligible studies for this question.

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Fluoroquinolones vs amoxicillin

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 83 participants
  Low

Fluoroquinolones vs amoxicillin

Fluoroquinolones may leads to lower response rate ‐ treatment failure compared with amoxicillin (low certainty).

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.07 [0.01, 0.32]
  2 studies · 83 participants
  Low

Fluoroquinolones vs amoxicillin

Fluoroquinolones may leads to higher response rate ‐ microbiological response compared with amoxicillin (low certainty).

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  Peto OR 20.09 [2.83, 142.59]
  1 study · 16 participants
  Low

Fluoroquinolones vs amoxicillin

It is very uncertain whether fluoroquinolones changes response rate ‐ improvement in sputum purulence (excellent) compared with amoxicillin (very low certainty).

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 2.35 [0.96, 5.72]
  2 studies · 83 participants
  Very low

Fluoroquinolones vs amoxicillin

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 83 participants
  Low

Fluoroquinolones vs amoxicillin

The review found no eligible studies for this question.

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Polymyxins vs aminoglycosides

The review found no eligible studies for this question.

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Polymyxins vs aminoglycosides

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Ceftriaxone showed no clear difference in death ‐ in all participants ‐ short term compared with long‐acting (oily) chloramphenicol (moderate certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  RR 1.21 [0.57, 2.56]
  1 study · 503 participants
  Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Ceftriaxone showed no clear difference in death ‐ in confirmed cases of meningococcal meningitis (subgroup) compared with long‐acting (oily) chloramphenicol (moderate certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  RR 1.11 [0.35, 3.56]
  1 study · 308 participants
  Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Ceftriaxone showed no clear difference in clinical failure ‐ in all participants ‐ short term Composite… compared with long‐acting (oily) chloramphenicol (moderate certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  OR 0.83 [0.32, 2.15]
  1 study · 477 participants
  Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Ceftriaxone showed no clear difference in clinical failure ‐ in confirmed cases of meningococcal meningitis… compared with long‐acting (oily) chloramphenicol (moderate certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  OR 1.39 [0.23, 8.47]
  1 study · 308 participants
  Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Ceftriaxone showed no clear difference in neurological sequelae ‐ in all participants‐ short term Clinical… compared with long‐acting (oily) chloramphenicol (low certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  RR 1.29 [0.63, 2.62]
  1 study · 477 participants
  Low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

It is very uncertain whether ceftriaxone changes neurological sequelae ‐ in confirmed cases of meningococcal… compared with long‐acting (oily) chloramphenicol (very low certainty).

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  RR 1.44 [0.65, 3.23]
  1 study · 297 participants
  Very low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

• Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 1 participants
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
  no estimate extracted
  6618 participants
  Moderate

Intervention not reported

• Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
  no estimate extracted
  77015 participants
  Moderate