Findings

What do systematic reviews say?

2,447 questions · 2,590 findings · 266 reviews

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No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Viaskin milk patch vs placebo

Clinical improvement (dichotomous) · active EoE pediatric patients

The review found no eligible studies for this question.

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Viaskin milk patch vs placebo

Clinical improvement (continuous) · active EoE pediatric patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

Viaskin milk patch vs placebo

Histological improvement (dichotomous) · active EoE pediatric patients

The review found no eligible studies for this question.

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Viaskin milk patch vs placebo

Histological improvement (continuous) · active EoE pediatric patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

Viaskin milk patch vs placebo

Endoscopic improvement (dichotomous) · active EoE pediatric patients

The review found no eligible studies for this question.

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Viaskin milk patch vs placebo

Endoscopic improvement (continuous) · active EoE pediatric patients

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Viaskin milk patch vs placebo

Withdrawals due to adverse events · active EoE pediatric patients

Viaskin milk patch showed no clear difference in withdrawals due to adverse events at 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
RR 1.12 [0.05, 23.99]
1 study · 20 participants
Low

Leukotriene receptor antagonist vs placebo

Clinical improvement (dichotomous) · inactive EoE patients

It is very uncertain whether leukotriene receptor antagonist changes clinical improvement at 26 weeks (dichotomous) compared with placebo (very low certainty).

1 finding from 1 review

Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
RR 1.68 [0.66, 4.28]
1 study · 41 participants
Very low

Motivational interviewing vs other active intervention

Extent of substance use at short‐term · people with substance use (adults, young adults, adolescents)

2 findings from 1 review

Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 338 participants
Low
Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
18 studies · 2795 participants
Low

Motivational interviewing vs other active intervention

Extent of substance use at medium‐term · people with substance use (adults, young adults, adolescents)

1 finding from 1 review

Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 2352 participants
Low

Motivational interviewing vs other active intervention

Extent of substance use at long‐term · people with substance use (adults, young adults, adolescents)

1 finding from 1 review

Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1908 participants
Low

Motivational interviewing vs other active intervention

Readiness to change (0‐ to 3‐month · people with substance use (adults, young adults, adolescents)

1 finding from 1 review

Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 988 participants
Low

Motivational interviewing vs other active intervention

Retention in treatment · people with substance use (adults, young adults, adolescents)

1 finding from 1 review

Motivational interviewing for substance use reduction 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 1945 participants
Moderate

SPLINT vs No active treatment (control)

CTS symptoms (Boston CTS questionnaire) ‐ short‐term improvement: < 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 306 participants
Low

SPLINT vs No active treatment (control)

CTS symptoms (Boston CTS questionnaire) ‐ long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 144 participants
Very low

SPLINT vs No active treatment (control)

Function (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

SPLINT vs No active treatment (control)

Overall improvement (improved/not improved or worsened) ‐ short‐term improvement: < 3 months · carpal tunnel syndrome

SPLINT may leads to higher overall improvement (improved/not improved or worsened) ‐ short‐term… compared with NO ACTIVE TREATMENT (low certainty).

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
RR 3.86 [2.29, 6.51]
1 study · 80 participants
Low

SPLINT vs No active treatment (control)

Health‐related quality of life ‐ Long‐term improvement: > 3 months · carpal tunnel syndrome

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

SPLINT vs No active treatment (control)

Adverse effects · carpal tunnel syndrome

SPLINT showed no clear difference in adverse effects compared with NO ACTIVE TREATMENT (low certainty).

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
RR 15 [0.89, 254.13]
1 study · 80 participants
Low

SPLINT vs No active treatment (control)

Referral for surgery · carpal tunnel syndrome

It is very uncertain whether SPLINT changes referral for surgery compared with NO ACTIVE TREATMENT (very low certainty).

1 finding from 1 review

Splinting for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
RR 0.47 [0.14, 1.58]
3 studies · 243 participants
Very low