Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Pregabalin 300 mg vs placebo

Patient satisfaction with analgesia ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in patient satisfaction with analgesia compared with placebo (low certainty).

1 finding from 1 review

Dental caries vs Caries-free status

Relative abundance of S. mutans in saliva · Systemically healthy individuals (children and adults, aged 40 months to 50 years) assessed for dental caries

The relative abundance of S. mutans in saliva is significantly higher in caries-active than caries-free individuals (pooled SMD 1.48, 95% CI 0.45 to 2.50), but heterogeneity is very high (I2=90%); ungraded.

1 finding from 1 review

Dental caries vs Caries-free status

Oral microbial community composition and diversity (other caries-associated taxa; alpha- and beta-diversity) · Systemically healthy individuals (children and adults, aged 40 months to 50 years) assessed for dental caries

No oral microbial taxon other than S. mutans was consistently associated with caries; alpha-diversity mostly did not differ between caries-active and caries-free groups and beta-diversity findings were mixed (ungraded, narrative).

1 finding from 1 review
  • Streptococcus mutans and Caries: A Systematic Review and Meta-Analysis. 2025 All outcomes
    Cross-sectional · Clinical oral-microbiome studies; saliva and/or supragingival plaque samples; 7 countries; DNA/RNA-based sequencing or microarray
    Narrative synthesis (no pooled estimate): no bacterial genus or species other than S. mutans was consistently (reported in more than 2 studies) associated with caries-active status (Table 3; 15 of 19 studies for…
    Studies not reported
    GRADE not reported

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Total mortality · Adults with oral cavity cancer
1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Adverse events associated with treatment · Adults with oral cavity cancer
1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Recurrence · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes recurrence compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

Genetically predicted pulp and periapical diseases vs Without pulp and periapical diseases (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted pulp and periapical diseases were associated with modestly higher odds of lacunar stroke (OR 1.20); ungraded MR, FDR-adjusted P 0.033.

1 finding from 1 review