Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Neoadjuvant immunotherapy (high dose interferon) plus chemotherapy vs neoadjuvant chemotherapy

Overall response rate (ORR), · stage III and IV cutaneous melanoma

It is very uncertain whether neoadjuvant immunotherapy (high dose interferon) plus chemotherapy changes overall response rate (ORR), measured after 8 weeks of treatment and… compared with neoadjuvant chemotherapy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

It is very uncertain whether summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy changes any severe adverse event (grade 3 or higher) (G3+ SevAE ) compared with placebo (maintenance therapy) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Overall survival (OS) · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy showed no clear difference in overall survival (OS) compared with placebo (maintenance therapy) (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Progression‐free survival · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy may leads to lower progression‐free survival (PFS) compared with placebo (maintenance therapy) (low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Healing of MRONJ · People with established (manifest) MRONJ

It is very uncertain whether hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy changes healing of MRONJ compared with conventional therapy (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Mortality (proportion of participants dying in each group at · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in mortality (proportion of participants dying in each group at compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Surgical site infection · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy probably leads to lower surgical site infection (proportion of participants in each group… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Wound dehiscence · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in dehiscence (proportion of participants in each group with wound… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Seroma (proportion of participants in each group with seroma; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in seroma (proportion of participants in each group with seroma; compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Haematoma (proportion of participants in each group with haematoma; · adult patients with surgical wounds healing by primary closure

It is very uncertain whether negative pressure wound therapy changes haematoma (proportion of participants in each group with haematoma; compared with standard dressing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Skin blisters (proportion of participants in each group with at least one skin blister; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy may leads to higher skin blisters (proportion of participants in each group with at… compared with standard dressing (low certainty).

1 finding from 1 review

Electromechanical‐ and robotic‐assisted gait training plus physiotherapy vs usual care or physiotherapy

Independent walking (primary outcome) · patients with walking after stroke

Electromechanical‐ and robot‐assisted gait training plus physiotherapy leads to higher independent walking (primary outcome) compared with physiotherapy (or usual care) (high certainty).

1 finding from 1 review