Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

CBT vs active control

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT) analysis i.e. no longer meeting… compared with active controls (moderate certainty).

1 finding from 1 review

CBT vs treatment

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with treatment (moderate certainty).

1 finding from 1 review

Chondroitin vs placebo

Pain on a 0 to 100 scale ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis
1 finding from 1 review

Chondroitin vs placebo

WOMAC MCII Pain subscale (reduction in knee pain by 20%) ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis

Chondroitin leads to higher WOMAC MCII Pain subscale (reduction in knee pain by 20%) ‐ Long‐term… compared with placebo (high certainty).

1 finding from 1 review

Chondroitin vs placebo

Radiographic Outcome: Reduction in Minimum Joint Space Width (JSW) in mm ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d Scale: millimeters (smaller decrease in reduction in minimum joint space width is better) · patients with osteoarthritis
1 finding from 1 review

Chondroitin with or without glucosamine vs placebo or control

WOMAC MCII Pain subscale (reduction in knee pain by 20%) ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis

Chondroitin with or without glucosamine leads to higher WOMAC MCII Pain subscale (reduction in knee pain by 20%) Long‐term… compared with placebo/control (high certainty).

1 finding from 1 review

Cells vs no cells

All‐cause mortality ‐ long‐term · Anyone diagnosed with AMI

Cells showed no clear difference in all‐cause mortality ‐ long‐term compared with no cells (moderate certainty).

1 finding from 1 review

Cells vs no cells

Cardiovascular mortality · Anyone diagnosed with AMI

Cells showed no clear difference in cardiovascular mortality ‐ long‐term compared with no cells (moderate certainty).

1 finding from 1 review

Cells vs no cells

Composite death, reinfarction and hospitalisation for heart failure ‐ long‐term · Anyone diagnosed with AMI

Cells showed no clear difference in composite death, reinfarction and hospitalisation for heart failure… compared with no cells (moderate certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Survival (long term) Over two years · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in survival (long term) Over two years compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review