Xerostomia (dry mouth relief) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Johnson 1993: positive response (>25 mm change in VAS score) in 25% of participants on placebo, 51% on pilocarpine 5 mg tds, 47% on pilocarpine 10 mg tds. LeVeque 1993: positive response in 7% on placebo vs 42% on…
2 studies · 278 participants
GRADE not reported
Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Both studies assessed oral discomfort and dysphonia (Johnson 1993; LeVeque 1993); pilocarpine reported to improve associated symptoms of salivary gland dysfunction (oral discomfort, dysphonia). No pooled data.
2 studies · 278 participants
GRADE not reported
Salivary flow rate · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Intervention not reported
Preterm birth (< 37 weeks gestation) (Any psychosocial intervention vs. control)
The intervention showed no clear difference in preterm birth (< 37 weeks gestation) (Any psychosocial intervention… (moderate certainty).
1 finding from 1 review
Intervention not reported
Low birth weight (< 2500 g) (Any psychosocial intervention vs. control)
The intervention showed no clear difference in low birth weight (< 2500 g) (Any psychosocial intervention vs.… (high certainty).
1 finding from 1 review
Intervention not reported
Days hospitalized after delivery (Any psychosocial intervention vs. control)
The intervention showed no clear difference in days hospitalized after delivery (Any psychosocial intervention vs.… (moderate certainty).
1 finding from 1 review
Intervention not reported
Positive urine at delivery (Any psychosocial intervention vs. control)
The intervention showed no clear difference in positive urine at delivery (Any psychosocial intervention vs. control) (high certainty).
1 finding from 1 review
Intervention not reported
Change in nausea severity at 30 minutes Visual analogue scale Scale from: 0 to 100 · people with nausea and vomiting
1 finding from 1 review
Intervention not reported
Number of vomiting episodes · people with nausea and vomiting
1 finding from 1 review
Intervention not reported
Adverse reactions · people with nausea and vomiting
1 finding from 1 review
Intervention not reported
Proportion of participants requiring rescue medication Physician's discretion · people with nausea and vomiting
The intervention may leads to lower proportion of participants requiring rescue medication Physician's… (low certainty).
1 finding from 1 review
Intervention not reported
Participant satisfaction with intervention Self report · people with nausea and vomiting
The intervention showed no clear difference in participant satisfaction with intervention Self report (low certainty).
1 finding from 1 review
Other oral symptoms (dysgeusia, dysphagia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Dry mouth (xerostomia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Davies 1994 (cross-over, 20 participants): mean improvement in VAS score 22.5 mm with pilocarpine vs 15.2 mm with artificial saliva (100 mm scale). The improvement was greater with pilocarpine but was not statistically…
1 study · 20 participants
GRADE not reported
Intervention not reported
Mortality All‐cause death · Pregnant women (parity 0‐1)
It is very uncertain whether the intervention changes mortality All‐cause death (very low certainty).
1 finding from 1 review
Intervention not reported
Neonatal mortality · Pregnant women (parity 0‐1)
The intervention showed no clear difference in neonatal mortality (low certainty).
1 finding from 1 review
Intervention not reported
Preterm birth · Pregnant women (parity 0‐1)
The intervention showed no clear difference in preterm birth (low certainty).
1 finding from 1 review
Intervention not reported
Low birthweight · Pregnant women (parity 0‐1)
The intervention probably leads to lower low birthweight (moderate certainty).
1 finding from 1 review
Intervention not reported
Mean birthweight · Pregnant women (parity 0‐1)
1 finding from 1 review
Intervention not reported
Placental parasitaemia · Pregnant women (parity 0‐1)
The intervention leads to lower placental parasitaemia (high certainty).
1 finding from 1 review