Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Light-emitting diode (LED) photobiomodulation vs Conventional orthodontic appliance treatment

Rate of orthodontic tooth movement during space closure stage (maxillary canine distalisation), mm/day · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether light-emitting diode (LED) photobiomodulation changes rate of orthodontic tooth movement during space closure stage… compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review

Neocone vs Alvogyl

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to complete resolution of pain (days) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Perioperative ipsilateral stroke (< 30 days) · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Occlusion of the operated artery within 30 days of operation · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

Main comparison of patch angioplasty may leads to lower occlusion of the operated artery within 30 days of operation compared with primary closure (low certainty).

1 finding from 1 review

Shunting vs no shunting

Stroke‐related death within 30 days of surgery (best‐case) · patients with symptomatic or asymptomatic carotid disease

Shunting may leads to lower stroke‐related death within 30 days of surgery (best‐case) compared with no shunting (low certainty).

1 finding from 1 review

Shunting vs no shunting

Stroke‐related death within 30 days of surgery (worst‐case) · patients with symptomatic or asymptomatic carotid disease

Shunting showed no clear difference in stroke‐related death within 30 days of surgery (worst‐case) compared with no shunting (low certainty).

1 finding from 1 review

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 3 days of treatment (included children 2 to… compared with placebo (low certainty).

1 finding from 1 review

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation: after 5 days of treatment (included children 2 to 12 years old only) · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 5 days of treatment (included children 2 to… compared with placebo (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Mortality ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in mortality ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Rebleeding · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in rebleeding ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review