Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Acute respiratory infections study duration: 12 months · patients with chronic obstructive pulmonary disease

It is very uncertain whether PPI plus usual care changes acute respiratory infections study duration: 12 months compared with usual care alone or chronic obstructive pulmonary disease (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).

5 findings from 2 reviews · compare the 2 reviews
Show 2 more findings

Self‐management interventions vs usual care

Respiratory‐related hospital admissions · patients with chronic obstructive pulmonary disease

It is very uncertain whether self‐management interventions changes respiratory‐related hospital admissions compared with usual care (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Self‐management interventions vs usual care

Respiratory‐related mortality · patients with chronic obstructive pulmonary disease

Self‐management interventions showed no clear difference in respiratory‐related mortality compared with usual care (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Self‐management interventions vs usual care

All‐cause mortality · patients with chronic obstructive pulmonary disease

Self‐management interventions showed no clear difference in all‐cause mortality compared with usual care (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Self‐management interventions vs usual care

Hospital admissions · patients with chronic obstructive pulmonary disease

Self‐management interventions showed no clear difference in all‐cause hospital admissions compared with usual care (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Self‐management interventions vs usual care

COPD exacerbations · patients with chronic obstructive pulmonary disease
2 findings from 2 reviews · compare the 2 reviews

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Postoperative pain (patient-reported) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

The effect of material choice (MTA vs CaOH) on postoperative pain is unclear: two small studies used different methods and reported contradictory results, so no meta-analysis was performed (ungraded).

1 finding from 1 review

Hydraulic calcium silicate cements (HCSC; MTA or Biodentine) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

At 36-month follow-up, HCSC show higher odds of clinical and radiographic success than CaOH (OR 2.34, 95% CI 1.43 to 3.84; ungraded subgroup).

3 findings from 1 review

Biodentine vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

Biodentine and calcium hydroxide did not differ significantly in clinical and radiographic success (OR 3.14, 95% CI 0.91 to 10.86; ungraded subgroup analysis).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

Mineral trioxide aggregate shows higher odds of clinical and radiographic success than calcium hydroxide (OR 3.05, 95% CI 1.70 to 5.45; ungraded subgroup analysis).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Mortality within the longest · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in all‐cause mortality (during the index hospital admission, or within… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Cardiac complications (as defined by study authors, including cardiac compromise and fatal and non‐fatal myocardial infarction, defined as ECG changes, echocardiological changes, or disproportionate elevation of troponins, during the index hospita... · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids may leads to higher cardiac complications (as defined by study authors, including… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Infectious complications · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids may leads to lower infectious complications (as defined by study authors, including… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Gastrointestinal bleeding · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in gastrointestinal (GI) bleeding (as defined by study authors,… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Renal failure · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in renal failure (as defined by study authors, including dialysis,… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review