Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Intervention not reported

Mean change in visual fields at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Antipsychotics vs placebo

Dropout · patients with the treatment of cocaine dependence

Any antipsychotic probably leads to lower dropouts Number of participants who dropped out from the study compared with placebo (moderate certainty).

1 finding from 1 review

Antipsychotics vs placebo

Participants with at least some Side Effects · patients with the treatment of cocaine dependence

Any antipsychotic showed no clear difference in side effects Number of participants with at least i side effect compared with placebo (low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with the treatment of cocaine dependence

Any antipsychotic showed no clear difference in number of participants using cocaine during the treatment (as… compared with placebo (low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Continuous abstinence (number of participants who maintained negative drug screens for 2 ‐ 3 weeks) Number of participants that maintained negative cocaine screens for at least 2 ‐ 3 weeks · patients with the treatment of cocaine dependence

Any antipsychotic showed no clear difference in continuous abstinence (number of participants who maintained… compared with placebo (low certainty).

1 finding from 1 review