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What do systematic reviews say?

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Evidence found and GRADE certainty

1,296 questions · 1,330 findings · 157 reviews · Headline outcomes only

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No studies found 297 · 22.3%GRADE not reported 88 · 6.6%Very low 327 · 24.6%Low 317 · 23.8%Moderate 239 · 18%High 62 · 4.7%

Doxycycline vs tetracycline

Resolution of fever within 48 hours · adults with scrub typhus

Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Intervention not reported

Death · children and adults with acute bacterial meningitis

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological disability · children and adults with acute bacterial meningitis

The intervention showed no clear difference in neurological disability (low certainty).

1 finding from 1 review

Intervention not reported

Hearing loss · children and adults with acute bacterial meningitis

The intervention probably leads to lower hearing loss (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: nausea, vomiting, diarrhoea · children and adults with acute bacterial meningitis

It is very uncertain whether the intervention changes adverse effects: nausea, vomiting, diarrhoea (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: gastrointestinal bleeding · children and adults with acute bacterial meningitis

The intervention showed no clear difference in adverse effects: gastrointestinal bleeding (moderate certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral amoxicillin plus oral probenecid

Cure of gonococcal infection (microbiological culture) · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes cure of gonococcal infection (microbiological culture) compared with oral amoxicillin plus oral probenecid (very low certainty).

1 finding from 1 review