What do systematic reviews say?

Non‐platinum single‐agent vs non‐platinum combination treatment

It is very uncertain whether non‐platinum single‐agent changes grade 3 and 4 hematological adverse events (AE) ‐ thrombocytopenia compared with non‐platinum combination treatment (very low certainty).

• Chemotherapy for advanced non‐small cell lung cancer in the elderly population 2015 · Cochrane Headline outcomes only
  RR 1.58
  4 studies · 995 participants
  Very low

Non‐platinum single‐agent vs non‐platinum combination treatment

• Chemotherapy for advanced non‐small cell lung cancer in the elderly population 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  GRADE not reported

Non‐platinum therapies vs platinum combination

Non‐platinum therapies probably leads to lower overall survival compared with platinum combination (moderate certainty).

• Chemotherapy for advanced non‐small cell lung cancer in the elderly population 2015 · Cochrane Headline outcomes only
  HR 0.76
  13 studies · 13 participants
  Moderate

Azoles vs moderate‐potent corticosteroid/azole combinations

Azoles showed no clear difference in mycological cure Negative KOH microscopy and culture. Treatment… compared with moderate‐potent corticosteroid/azole combinations (low certainty).

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  RR 0.99 [0.93, 1.05]
  6 studies · 625 participants
  Low

Azoles vs moderate‐potent corticosteroid/azole combinations

It is very uncertain whether azoles changes clinical cure (immediately at end of treatment) Resolution of… compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  RR 0.67 [0.53, 0.84]
  4 studies · 353 participants
  Very low

Azoles vs moderate‐potent corticosteroid/azole combinations

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  RR 1.36 [0.68, 2.69]
  5 studies · 668 participants
  Very low

Azoles vs moderate‐potent corticosteroid/azole combinations

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Azoles vs moderate‐potent corticosteroid/azole combinations

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 1 participants
  Low

Azoles vs moderate‐potent corticosteroid/azole combinations

• Topical antifungal treatments for tinea cruris and tinea corporis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Antidepressants vs a combination of medications

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 107 participants
  Low

Antidepressants vs a combination of medications

Antidepressants showed no clear difference in acceptability (all‐cause drop‐outs4) compared with a combination of medications (low certainty).

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  RR 0.8 [0.25, 2.52]
  2 studies · 118 participants
  Low

Antidepressants vs a combination of medications

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 107 participants
  Very low

Antidepressants vs a combination of medications

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 107 participants
  Very low

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found