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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

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No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEI had disappeared within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Intranasal steroid spray vs placebo or no intervention

Change in sense of smell · people with olfactory dysfunction for less than 4 weeks following COVID‐19 infection
2 findings from 1 review

Lateral postures vs other postures

Severe perineal tears (3rd degree or higher, as defined by trialists) · fetal malposition in labour

It is very uncertain whether lateral postures changes severe perineal tears (3rd degree or higher, as defined by trialists) compared with other postures (very low certainty).

1 finding from 1 review

Hands and knees posture vs other postures

Severe perineal tears (3rd degree or higher, as defined by trialists) · fetal malposition in labour

It is very uncertain whether hands and knees posture changes severe perineal tears (3rd degree or higher, as defined by trialists) compared with other postures (very low certainty).

1 finding from 1 review

Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroids

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether non‐biologic disease‐modifying antirheumatic drugs (DMARDs) changes proportion of participants achieving control of inflammation (higher… compared with steroid (very low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving steroid‐sparing control§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving control of inflammation (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving steroid‐sparing control (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroids

Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).

1 finding from 1 review