Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,352 questions · 1,400 findings · 169 reviews

No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Intervention not reported

Ear pain (otalgia) or discomfort or local irritation · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Hearing · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious complications · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Suspected ototoxicity · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty
1 finding from 1 review

Quinolone vs aminoglycosides

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

It is very uncertain whether quinolones changes resolution of ear discharge ‐ measured at 1 to 2 weeks compared with aminoglycosides (very low certainty).

1 finding from 1 review

Intervention not reported

Resolution of ear discharge‐ measured at 1 to 2 weeks · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The intervention may leads to higher resolution of ear discharge‐ measured at 1 to 2 weeks (low certainty).

1 finding from 1 review

Intervention not reported

Resolution of ear discharge ‐ measured after 4 weeks · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs placebo or no treatment

Recurrence of symptomatic UTI in children · children with previous UTI and most do not have a renal tract abnormality such as VUR

Antibiotic treatment showed no clear difference in recurrence of symptomatic UTI in children compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (moderate certainty).

2 findings from 1 review

Antibiotic 1 vs antibiotic 2

Microbial resistance to prophylactic drugs: nitrofurantoin (1) versus cotrimoxazole (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 probably leads to lower microbial resistance to prophylactic drugs: nitrofurantoin (1)… compared with antibiotic 2 (moderate certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in adverse events: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: nitrofurantoin (1) versus trimethoprim (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 may leads to higher adverse events: nitrofurantoin (1) versus trimethoprim (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Recurrence of symptomatic UTI in children without VUR · children with previous UTI and most do not have a renal tract abnormality such as VUR

Antibiotic treatment showed no clear difference in recurrence of symptomatic UTI in children without VUR compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Recurrence of symptomatic UTI in children with VUR · children with previous UTI and most do not have a renal tract abnormality such as VUR

Antibiotic treatment showed no clear difference in recurrence of symptomatic UTI in children with VUR compared with placebo or no treatment (low certainty).

1 finding from 1 review