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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CCPT vs PEP FEV1: change from baseline in FEV1 % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 studies · 169 participants | Very low |
CCPT vs extrapulmonary mechanical percussion FEF25–75: rate of decline in FEF25–75 · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 151 participants | Very low |
CCPT vs extrapulmonary mechanical percussion Respiratory exacerbations: time to first treatment with IV antibiotics · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 151 participants | Very low |
CCPT vs extrapulmonary mechanical percussion QoL: change in CFQ score · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 151 participants | Very low |
CCPT vs extrapulmonary mechanical percussion Adherence to therapy and individual preference (change in adherence rate and TSS score) · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 131 participants | Very low |
CCPT vs extrapulmonary mechanical percussion Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs ACBT FEV1: annual decline in FEV1 % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | MD 2.8 | 1 study · 63 participants | Very low |
CCPT vs ACBT FVC: annual decline in FVC % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | MD 1.8 | 1 study · 63 participants | Very low |
CCPT vs ACBT FEF25–75: annual decline in FEF25–75 % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | MD 6 [0.55, 11.45] | 1 study · 63 participants | Very low |
CCPT vs ACBT Respiratory exacerbations: time to first exacerbation · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs ACBT QoL: change in CFQ score · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs PEP FVC: change from baseline in FVC % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 studies · 169 participants | Very low |
CCPT vs ACBT Adherence to therapy and individual preference: self‐reported scoring system. · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | Very low |
CCPT vs ACBT Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs O‐PEP devices FEV1: % predicted at end of study · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 3 studies · 185 participants | Very low |
CCPT vs O‐PEP devices FVC: % predicted at end of study · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 3 studies · 185 participants | Very low |
CCPT vs O‐PEP devices FEF25–75: at end of the study · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 2 studies · 171 participants | Very low |
CCPT vs O‐PEP devices Respiratory exacerbations: number of respiratory exacerbations per year · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs O‐PEP devices QoL: change in CFQ score (across 12 domains) · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 155 participants | Very low |
CCPT vs O‐PEP devices Adherence to therapy and individual preference: TSS score · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 155 participants | Very low |
CCPT vs O‐PEP devices Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 14 participants | Very low |
CCPT vs AD FEV1: % predicted · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
CCPT vs PEP FEF25–75: change from baseline in FEF25–75 · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 4 studies · 87 participants | Very low |
CCPT vs AD FVC: % predicted · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
CCPT vs AD FEF25–75: % predicted · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
CCPT vs AD Respiratory exacerbations: number of respiratory exacerbations per year · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs AD QoL · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs AD Adherence to therapy and individual preference · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 36 participants | Very low |
CCPT vs AD Mucus weight · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FEV1 · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FVC · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FEF25–75 · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Respiratory exacerbations: number of respiratory exacerbations per year · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs PEP Respiratory exacerbations: number of respiratory exacerbations per year · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise QoL · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Adherence to therapy and individual preference · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Mucus weight · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs PEP QoL: change in QWB · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 66 participants | Very low |
CCPT vs PEP Adherence to therapy and individual preference · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 8 studies · 224 participants | Very low |
CCPT vs PEP Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 4 studies · 75 participants | Very low |
CCPT vs extrapulmonary mechanical percussion FEV1: rate of decline in FEV1 % predicted · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 151 participants | Very low |
CCPT vs extrapulmonary mechanical percussion FVC: rate of decline in FVC % predicted. · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 151 participants | Very low |
Inhaled tobramycin (TNS) vs placebo Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.06 [0.02, 0.18] | 3 studies · 89 participants | Low |
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days) FVC: % predicted · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 88 participants | Very low |
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days) Growth and nutritional status: weight, height and BMI · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 88 participants | Very low |
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days) Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.19 [0.01, 4] | 1 study · 77 participants | Very low |
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days) Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 88 participants | Very low |
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days) Adverse effects of antibiotics · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 77 participants | Very low |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS FEV1: mean 70‐week % change in FEV1 (% predicted) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 143 participants | Low |