Search review questions

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · Adult patients with major depressive disorder (MDD)

Trial non‐completionStudy reports · Adult patients with major depressive disorder (MDD)

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) or similar (no. of responders) · adults with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) · adults with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · adults with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) · adults with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · adults with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) · children and adolescents with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children and adolescents with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventscDropout rate · children and adolescents with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) & NIMH Trichotillomania Severity Scale (NIMH‐TSS) (no. of responders as > 50% reduction) · adults with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse events · adults with trichotillomania

Treatment response · adults with trichotillomania

Reduction of TTM symptom severityaMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) mean change score · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventseDropout rate · adults with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CG‐I) (no. of responders) · adults with trichotillomania

Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsdDropout rate · adults with trichotillomania

Treatment responseaPhysician‐rated Clinical Progress Scale · adults with trichotillomania

Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · adults with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) or similar (no. of responders) · children with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · children with trichotillomania

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) · adults with trichotillomania

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

Tolerability of treatment ‐ dropouts due to adverse eventsDropout rate · adults with trichotillomania

Response (> 50% improvement on 29‐item HAM‐D SIGH‐SAD) · adults with seasonal affective disorder

Remission (response plus end score 8 or less) · adults with seasonal affective disorder

Time to onset of response · adults with seasonal affective disorder

Adverse events (at least 1 treatment‐emergent adverse event) · adults with seasonal affective disorder

Clinical Global Impression – Improvement score · adults with seasonal affective disorder

Quality of life · adults with seasonal affective disorder

Remission · adults with seasonal affective disorder

Speed of onset of response · adults with seasonal affective disorder

Overall adverse events 5 weeks · adults with seasonal affective disorder

Response (> 50% improvement on 24‐item HAM‐D SIGH‐SAD) · adults with seasonal affective disorder

Clinical Global Impression – Improvement score · adults with seasonal affective disorder

Quality of life (SF‐20 and Q‐LES‐Q) · adults with seasonal affective disorder

Incidence of depression ‐ post‐intervention: 0 months · adults with long‐term physical conditions (18 years or older)

Incidence of depression ‐ short‐term: < 6 months · adults with long‐term physical conditions (18 years or older)

Incidence of depression ‐ medium‐term: 6‐12 months · adults with long‐term physical conditions (18 years or older)

Incidence of depression ‐ long‐term: >12 months · adults with long‐term physical conditions (18 years or older)

tolerability ‐ total number of adverse events · adults with long‐term physical conditions (18 years or older)

acceptability ‐ drop‐outs due to adverse events: post‐intervention · adults with long‐term physical conditions (18 years or older)