Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

94 questions · 95 findings · 11 reviews · Pregnancy and Childbirth

No studies found 4 · 4.2%GRADE not reported 10 · 10.5%Very low 18 · 18.9%Low 36 · 37.9%Moderate 15 · 15.8%High 12 · 12.6%

Intervention not reported

Clinical pre‐eclampsia · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in clinical pre‐eclampsia (moderate certainty).

1 finding from 1 review

Intervention not reported

Placental abruption · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention leads to lower placental abruption (high certainty).

1 finding from 1 review

Oral calcium vs vitamin C

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).

1 finding from 1 review

Pyridoxine vs control

Pre‐eclampsia · pregnant women, either during the prenatal period or during labour.

Pyridoxine (B6) showed no clear difference in pre‐eclampsia ‐ Antenatal oral pyridoxine versus control compared with control (low certainty).

2 findings from 1 review

Pyridoxine vs control

Dental decay (increase in decayed, missing or filled teeth) ‐ Antenatal pyridoxine lozenges versus control · pregnant women, either during the prenatal period or during labour.

Pyridoxine (B6) may leads to lower dental decay (increase in decayed, missing or filled teeth) ‐… compared with control (low certainty).

1 finding from 1 review