Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

144 questions · 147 findings · 11 reviews

No studies found 45 · 30.6%GRADE not reported 16 · 10.9%Very low 35 · 23.8%Low 27 · 18.4%Moderate 16 · 10.9%High 8 · 5.4%

Efinaconazole 10% solution vs vehicle

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Efinaconazole 10% solution leads to higher adverse events (collected over the course of the studies; they are… compared with vehicle (high certainty).

1 finding from 1 review

Intervention not reported

Improvement in symptoms, reported by the child or by their parents/carers, preferably measured by a validated tool, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis
1 finding from 1 review

Intervention not reported

Elimination of all clinical signs of ocular surface inflammation ('complete success'), preferably measured by a composite grading system, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Improvement of clinical signs of ocular surface inflammation ('partial success'), preferably measured by a composite grading system, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis
1 finding from 1 review

Intervention not reported

Change from baseline in best corrected visual acuity in affected eye(s) in logMAR · children with blepharokeratoconjunctivitis
1 finding from 1 review

Intervention not reported

Uncontrolled or poorly controlled disease progression due to treatment failure, at three months (± one month) after start of treatment · children with blepharokeratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life · children with blepharokeratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid plus vitamin D leads to higher number of participants achieving 'response' by PGA compared with steroid (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid plus vitamin D leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid plus vitamin D leads to lower number of participants withdrawing due to adverse events compared with vitamin D (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by PGA compared with vitamin D (moderate certainty).

1 finding from 1 review