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What do systematic reviews say?

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Evidence found and GRADE certainty

246 questions · 262 findings · 25 reviews · Headline outcomes only

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No studies found 40 · 15.3%GRADE not reported 11 · 4.2%Very low 78 · 29.8%Low 74 · 28.2%Moderate 50 · 19.1%High 9 · 3.4%

Steroids vs lubricants

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Steroids vs lubricants

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids may leads to higher change in TBUT (seconds) (longer is favored) compared with lubricants (low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Steroids vs lubricants

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Adverse effect: cataract · people with dry eye

It is very uncertain whether steroids changes adverse effect: new cataract formation ( compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid leads to higher number of participants achieving 'response' by IGA compared with vitamin D (high certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid probably leads to lower number of participants withdrawing due to adverse events (AE) compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'response' by PGA compared with vitamin D (moderate certainty).

1 finding from 1 review