What do systematic reviews say?

Chinese herbal medicines vs placebo

• Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

Chinese herbal medicines vs placebo

• Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

2 mm titanium plates vs 2.5 mm bioresorbable plates

2 mm titanium plates showed no clear difference in moderate soft tissue deformity compared with 2.5 mm bioresorbable plates; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  1 month
  RR 6.4 [0.80, 51.3]
  1 study · 57 participants
  GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  2 to 4 years
  Table 2: 77% (193) versus 75% (185) at follow-up (baseline 71% versus 69%). No significant change.
  1 study · 497 participants
  GRADE not reported

Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Er:YAG laser surface debridement before bone augmentation showed no clear difference in change in soft tissue recession (REC) compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  Six months after treatment there were no statistically significant differences for soft tissue recessions.
  1 study · 30 participants
  GRADE not reported

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

1-stage (non-submerged) implant placement showed no clear difference in aesthetics evaluated by dentists (soft tissue recession) compared with 2-stage (submerged) implant placement; GRADE not reported.

• Interventions for replacing missing teeth: 1- versus 2-stage implant placement 2009 · Cochrane All outcomes

  6 to 12 months after loading
  MD -0.20 [-0.67, 0.27]
  1 study · 29 participants
  GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

• Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
  Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
  Studies not reported
  GRADE not reported

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

• Fluoride toothpastes for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes

  At least 1 year
  Oral soft tissue lesions reported in 3 trials, none of which with complete or useable data; all three stated "no lesions attributable to product use were noted".
  3 studies
  GRADE not reported

Silicone hydrogel vs hydrogel soft contact lenses

The review found no eligible studies for this question.

• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Very low
• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  MD 0.55 [0.16, 0.94]
  1 study · 240 participants
  Very low

Silicone hydrogel vs hydrogel soft contact lenses

It is very uncertain whether silicone hydrogel changes proportion of participants who discontinued contact lens wear, at 1… compared with hydrogel soft contact lenses (very low certainty).

• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  RR 0.64 [0.11, 3.74]
  1 study · 248 participants
  Very low

Silicone hydrogel vs hydrogel soft contact lenses

It is very uncertain whether silicone hydrogel changes corneal staining scores, at 1 week (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 243 participants
  Very low

Silicone hydrogel vs hydrogel soft contact lenses

It is very uncertain whether silicone hydrogel changes conjunctival staining scores, at 1 month (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  MD 0.2
  1 study · 80 participants
  Very low

Silicone hydrogel vs hydrogel soft contact lenses

• Silicone hydrogel versus hydrogel soft contact lenses for differences in patient‐reported eye comfort and safety 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 participants
  Very low

NSAIDs vs paracetamol

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1178 participants
  High

NSAIDs vs opioid

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 706 participants
  Low

NSAIDs vs opioid

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 706 participants
  Low

NSAIDs vs opioid

It is very uncertain whether NSAID changes little or no swelling on day 7 or later compared with opioid (very low certainty).

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  RR 1.14 [0.61, 2.13]
  1 study · 84 participants
  Very low

NSAIDs vs opioid

NSAID may leads to higher return to function on day 7 or later (numbers returning to full… compared with opioid (low certainty).

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  RR 1.13 [1.03, 1.25]
  2 studies · 749 participants
  Low

NSAIDs vs opioid

NSAID probably leads to lower gastrointestinal adverse events compared with opioid (moderate certainty).

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  RR 0.48 [0.36, 0.62]
  5 studies · 1151 participants
  Moderate

NSAIDs vs opioid

NSAID probably leads to lower neurological adverse events compared with opioid (moderate certainty).

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  RR 0.4 [0.3, 0.53]
  5 studies · 1151 participants
  Moderate