Findings

What do systematic reviews say?

508 questions · 529 findings · 58 reviews

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No studies found 191 · 36.1%GRADE not reported 49 · 9.3%Very low 143 · 27%Low 92 · 17.4%Moderate 51 · 9.6%High 3 · 0.6%

Hypertonic saline vs mannitol

LCI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

All‐cause mortality · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

Measures of sputum clearance · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Hypertonic saline vs mannitol

Pulmonary exacerbations · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Mortality (short‐term) · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes mortality (short‐term) compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 0.33
2 studies · 70 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Mortality at 6 months · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes mortality at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 0.84 [0.46, 1.55]
2 studies · 85 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Glasgow Outcome Scale: poor outcome at 6 months · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes glasgow Outcome Scale: poor outcome at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 1.09 [0.82, 1.44]
2 studies · 85 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Uncontrolled ICP during treatment · people with acute traumatic brain injury

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 287 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

A rebound phenomenon during treatment · people with acute traumatic brain injury

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Pulmonary oedema · people with acute traumatic brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs other intracranial pressure‐lowering agents

Acute renal failure during treatment · people with acute traumatic brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

FEV1 % predicted: relative change from baseline · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Hypertonic saline 7% vs xylitol

FEV1 · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

LCI · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

All‐cause mortality · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

Measures of sputum clearance · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

Pulmonary exacerbations · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Hypertonic saline 7% vs xylitol

Adverse events: serious adverse events · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Saline vs other fluids

Death or dependence · people with acute stroke

0.9% saline showed no clear difference in death or dependence compared with other fluid (low certainty).

1 finding from 1 review

Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
OR 1.04 [0.82, 1.32]
3 studies · 1120 participants
Low