Overall survival · high‐grade glioma
It is very uncertain whether hypofractionated radiotherapy changes overall survival compared with daily conventionally fractionated radiotherapy (very low certainty).
1 finding from 1 review
Adverse effects · high‐grade glioma
1 finding from 1 review
Progression‐free survival · high‐grade glioma
1 finding from 1 review
Quality of life · high‐grade glioma
1 finding from 1 review
Overall survival for subgroup age 60 years and older glioblastoma · high‐grade glioma
Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).
1 finding from 1 review
Overall mortality ( · People with localised rectal carcinoma
Preoperative radiotherapy probably leads to lower overall mortality ( compared with surgery alone (moderate certainty).
1 finding from 1 review
Overall mortality ‐ only total mesorectal excision ( · People with localised rectal carcinoma
Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).
1 finding from 1 review
Cause‐specific mortality · People with localised rectal carcinoma
Preoperative radiotherapy showed no clear difference in cause‐specific mortality ( compared with surgery alone (low certainty).
1 finding from 1 review
Local recurrence · People with localised rectal carcinoma
Preoperative radiotherapy probably leads to lower local recurrence ( compared with surgery alone (moderate certainty).
1 finding from 1 review
Curative resection ( · People with localised rectal carcinoma
Preoperative radiotherapy showed no clear difference in curative resection ( compared with surgery alone (low certainty).
1 finding from 1 review
Sphincter preservation ( · People with localised rectal carcinoma
Preoperative radiotherapy showed no clear difference in sphincter preservation ( compared with surgery alone (low certainty).
1 finding from 1 review
Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma
Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).
1 finding from 1 review
Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma
Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).
1 finding from 1 review
Quality of life ( · People with localised rectal carcinoma
1 finding from 1 review
Ambulation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in ambulation One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Survival · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
1 finding from 1 review
Reduction in analgesic and narcotic use One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in reduction in analgesic and narcotic use One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in urinary continence One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Local recurrence · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in local recurrence MRI: compared with short‐course radiotherapy (16 Gy (low certainty).
1 finding from 1 review
Adverse events Grade 3 oesophagitis, diarrhoea and nausea · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in adverse events Grade 3 oesophagitis, diarrhoea and nausea compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review