What do systematic reviews say?

Topical quinolone vs boric acid

Topical antibiotics (quinolones) may leads to lower ear pain, discomfort, irritation compared with boric acid (low certainty).

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  RR 0.56 [0.32, 0.98]
  2 studies · 510 participants
  Low

Topical quinolone vs boric acid

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 390 participants
  Low

Topical quinolone vs boric acid

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs boric acid

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

It is very uncertain whether topical antibiotics (quinolones) changes resolution of ear discharge (1 to 2 weeks) compared with povidone‐iodine (very low certainty).

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  RR 1.02 [0.82, 1.26]
  1 study · 39 participants
  Very low

Topical quinolone vs povidone‐iodine

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Topical quinolone vs povidone‐iodine

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

It is very uncertain whether topical antibiotics (quinolones) changes suspected ototoxicity compared with povidone‐iodine (very low certainty).

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Topical quinolone vs boric acid

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 381 participants
  High

Intervention not reported

• Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 381 participants
  High

Intervention not reported

• Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 640 participants
  Moderate

Intervention not reported

• Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 640 participants
  Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

• Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
  RR 1.07
  10 studies · 917 participants
  Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

• Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
  RR 0.92
  10 studies · 931 participants
  Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Summary of findings: quinolone prophylaxis probably leads to lower bacteraemia compared with TMP‐SMZ prophylaxis (moderate certainty).

• Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
  RR 0.89
  10 studies · 931 participants
  Moderate

Cefixime vs fluoroquinolones

Cefixime may leads to higher clinical failure compared with fluoroquinolones (low certainty).

• Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
  RR 13.39 [3.24, 55.39]
  2 studies · 240 participants
  Low