Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

130 questions · 134 findings · 10 reviews · Haematology

No studies found 43 · 32.1%GRADE not reported 16 · 11.9%Very low 32 · 23.9%Low 30 · 22.4%Moderate 11 · 8.2%High 2 · 1.5%

Thromboelastography threshold vs standard of care (laboratory parameters)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes major bleeding within 24 hours № of participants: 60 (1 RCT) compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

Thromboelastography threshold may leads to lower number of individuals requiring a transfusion within 7 days № of… compared with standard of care (laboratory parameters) (low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes serious adverse events measured by plasma transfusion‐related… compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Thrombopoietin mimetics vs placebo or usual care

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with at least 1 bleeding episode compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with severe or life‐threatening bleeding (very low certainty).

1 finding from 1 review