Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 674 findings · 79 reviews · Gut

No studies found 116 · 17.2%GRADE not reported 14 · 2.1%Very low 133 · 19.7%Low 225 · 33.4%Moderate 145 · 21.5%High 41 · 6.1%

Infliximab 5–10 mg/kg vs placebo

Withdrawals due to adverse events · Patients with active Crohn's disease

The review found no eligible studies for this question.

2 findings from 1 review

Infliximab 5–10 mg/kg vs placebo

Clinical remission defined as absence of any draining fistulas at ≥ 2 consecutive visits, at a median 12 weeks · Patients with active Crohn's disease

It is very uncertain whether infliximab 5–10 mg/kg changes clinical remission defined as absence of any draining fistulas at ≥… compared with placebo (very low certainty).

1 finding from 1 review

Infliximab 5–10 mg/kg vs placebo

Clinical response defined as reduction of 50% in the number of draining fistula at ≥ 2 consecutive visits, at a median length of time of 12 weeks · Patients with active Crohn's disease

It is very uncertain whether infliximab 5–10 mg/kg changes clinical response defined as reduction of 50% in the number of… compared with placebo (very low certainty).

1 finding from 1 review

Synbiotic vs placebo

Severity of pain (at study end, using the Faces Pain Scale) · children (4 to 18 years) with functional abdominal pain disorders

It is very uncertain whether synbiotic changes severity of pain (at study end, using the Faces Pain Scale) compared with placebo (very low certainty).

1 finding from 1 review