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What do systematic reviews say?

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Evidence found and GRADE certainty

147 questions · 147 findings · 11 reviews

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No studies found 60 · 40.8%GRADE not reported 4 · 2.7%Very low 35 · 23.8%Low 40 · 27.2%Moderate 6 · 4.1%High 2 · 1.4%

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review