Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

97 questions · 104 findings · 13 reviews · Headline outcomes only

No studies found 7 · 6.7%GRADE not reported 8 · 7.7%Very low 24 · 23.1%Low 42 · 40.4%Moderate 13 · 12.5%High 10 · 9.6%

Varenicline vs e‐cigarettes

Smoking abstinence at longest · people who continued to smoke tobacco following acute coronary syndrome

It is very uncertain whether varenicline changes smoking abstinence at longest compared with e‐cigarettes (very low certainty).

1 finding from 1 review

Intervention not reported

Smoking cessation at 6+ months · people who smoke cigarettes

The intervention leads to higher smoking cessation at 6+ months (high certainty).

1 finding from 1 review