Failure to induce endoscopic remission · Patients with moderately to severely active ulcerative colitis
Vedolizumab leads to lower failure to induce endoscopic remission compared with placebo (high certainty).
1 finding from 1 review
Clinical relapse · Patients with moderately to severely active ulcerative colitis
Vedolizumab probably leads to lower clinical relapse compared with placebo (moderate certainty).
1 finding from 1 review
Endoscopic relapse · Patients with moderately to severely active ulcerative colitis
Vedolizumab probably leads to lower endoscopic relapse compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events · Patients with moderately to severely active ulcerative colitis
Vedolizumab showed no clear difference in adverse events compared with placebo (high certainty).
1 finding from 1 review
Serious adverse events · Patients with moderately to severely active ulcerative colitis
Vedolizumab showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Rate of admission during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) probably leads to lower rate of admission during ED stay compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
1 finding from 1 review
Rate of admission 72 hrs · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) showed no clear difference in rate of admission 72 hrs compared with placebo (low certainty).
2 findings from 1 review
Time to cessation of vomiting · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
1 finding from 1 review
Rate of intravenous rehydration during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) probably leads to lower rate of intravenous rehydration during ED stay compared with placebo (moderate certainty).
1 finding from 1 review
Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).
1 finding from 1 review
Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).
1 finding from 1 review
Proportion of patients with cessation of vomiting · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) probably leads to higher proportion of patients with cessation of vomiting compared with placebo (moderate certainty).
1 finding from 1 review
Revisit rate · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
Oral ondansetron (weight based) showed no clear difference in revisit rate compared with placebo (low certainty).
1 finding from 1 review