Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

163 questions · 167 findings · 14 reviews

No studies found 23 · 13.8%GRADE not reported 8 · 4.8%Very low 44 · 26.3%Low 65 · 38.9%Moderate 27 · 16.2%High 0 · 0%

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation without fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation without FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Apgar score less than 7 at 5 minutes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Sublingual misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Sublingual misoprostol showed no clear difference in women's dissatisfaction with the procedure compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Failure to achieve complete abortion · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower failure to achieve complete abortion compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower women's dissatisfaction with the procedure compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review