Findings

What do systematic reviews say?

4,771 questions · 10,185 findings · 893 reviews

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No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes menstruation recovery or maintenance: compared with chemotherapy alone (very low certainty).

2 findings from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 1 [0.76, 1.32]
1 study · 50 participants
Very low
Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 0.93 [0.56, 1.55]
1 study · 50 participants
Very low

Conventional chest physiotherapy plus routine treatment vs routine treatment alone

Duration of total antibiotic therapy ‐ not reported · people with pneumonia

The review found no eligible studies for this question.

1 finding from 1 review

Chest physiotherapy for pneumonia in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
1 year
This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
1 study · 26 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Blood lossTime point: mean 48 hours, range 1 to 13 days. Higher blood loss indicates a worse outcome. · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 956 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Pain at post‐operative day 2Scale from 0 (best) to 10 (worst). · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 530 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Transfusion rate · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes transfusion rate compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 2.13 [0.04, 109.63]
2 studies · 91 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Range of motion at discharge Scale from: 0 to 125. · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 174 participants
Low

Any cold therapy vs no cold therapy following total knee replacement

Function Standardised scale with positive score indicating a better outcome. Scale from 0 (worst) to 100 (best). · people undergoing total knee replacement

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 296 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes total adverse eventsAdverse events included discomfort, local skin… compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 1.3 [0.53, 3.2]
16 studies · 1199 participants
Very low

Any cold therapy vs no cold therapy following total knee replacement

Withdrawals due to adverse events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes withdrawals due to adverse events compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Cryotherapy following total knee replacement 2023 · Cochrane Headline outcomes only
RR 2.71 [0.42, 17.38]
19 studies · 1347 participants
Very low

Exercise therapy vs adaptive pacing therapy

Fatigue · men and women aged over 18 years with chronic fatigue syndrome

2 findings from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 305 participants
Low
Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 307 participants
Low

Exercise therapy vs adaptive pacing therapy

Participants with serious adverse reactions · men and women aged over 18 years with chronic fatigue syndrome

It is very uncertain whether exercise therapy changes participants with serious adverse reactions Measured after 52 weeks… compared with adaptive pacing therapy (very low certainty).

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
RR 0.99 [0.14, 6.97]
1 study · 319 participants
Very low

Exercise therapy vs adaptive pacing therapy

Pain End of treatment and long term · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise therapy vs adaptive pacing therapy

Physical functioning End of treatment and long term · men and women aged over 18 years with chronic fatigue syndrome

2 findings from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 305 participants
Low
Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 307 participants
Low

Exercise therapy vs adaptive pacing therapy

QoL · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise therapy vs adaptive pacing therapy

Depression Measured at end of treatment · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise therapy vs adaptive pacing therapy

Depression Measured after 52 weeks HADS depression score, 0‐21 points Low score means fewer symptoms · men and women aged over 18 years with chronic fatigue syndrome

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 293 participants
Low

Exercise therapy vs adaptive pacing therapy

Sleep · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

2 findings from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 294 participants
Low

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Number of unscheduled hospital admissions for 'maintenance therapy' · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cough augmentation therapy vs usual care

Peak cough flow for 'rescue' or 'maintenance' therapy · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found