It is very uncertain whether 6‐Mercaptopurine changes failure to maintain remission compared with methotrexate (very low certainty).
Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission1 compared with methotrexate (low certainty).
Azathioprine or 6‐mercaptopurine may leads to lower adverse events compared with methotrexate (low certainty).
It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
It is very uncertain whether 6‐Mercaptopurine changes maintenance of remission compared with methotrexate (very low certainty).
It is very uncertain whether 6‐Mercaptopurine changes adverse events compared with methotrexate (very low certainty).
It is very uncertain whether 6‐Mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
It is very uncertain whether 6‐Mercaptopurine changes serious adverse events compared with methotrexate (very low certainty).
Tranexamic acid probably leads to lower mortality Number of participants who died compared with cimetidine or lansoprazole (moderate certainty).
Tranexamic acid probably leads to lower rebleeding Clinical and endoscopic assessment compared with cimetidine or lansoprazole (moderate certainty).
Tranexamic acid probably leads to lower surgery Number of participants who underwent surgery compared with cimetidine or lansoprazole (moderate certainty).
Tranexamic acid may leads to lower transfusion Number of participants who required at least 1 blood… compared with cimetidine or lansoprazole (low certainty).
Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).
It is very uncertain whether the intervention changes sulfasalazine (2 RCTs; 143 participants) (very low certainty).
It is very uncertain whether the intervention changes antibiotics (2 RCTs; 57 participants) (very low certainty).
It is very uncertain whether the intervention changes probiotics (2 RCTs; 105 participants) (very low certainty).
It is very uncertain whether the intervention changes sulfasalazine + prednisolone (1 RCT; 57 participants) (very low certainty).
The intervention may leads to lower adalimumab (3 RCTs; 37 participants) (low certainty).