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Evidence found and GRADE certainty

143 questions · 144 findings · 9 reviews

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No studies found 41 · 28.5%GRADE not reported 8 · 5.6%Very low 26 · 18.1%Low 31 · 21.5%Moderate 25 · 17.4%High 13 · 9%

Lithium vs valproate

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    5 studies · 398 participants
    Very low

Lithium vs antipsychotics

> 50% reduction in depressive symptoms · schizophrenia

Lithium showed no clear difference in clinically significant response on depressive symptoms at least 50%… compared with antipsychotics (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Clinically significant response on manic symptoms at least 50% Bech‐Rafaelsen improvement · schizophrenia

Lithium showed no clear difference in clinically significant response on manic symptoms at least 50%… compared with antipsychotics (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia

Lithium may leads to lower clinically significant response on positive symptoms at least 50% MS… compared with antipsychotics (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Kidney dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Lithium vs antipsychotics

Thyroid dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Lithium vs antipsychotics

Response to treatment clinically relevant response as defined by the authors · schizophrenia

Lithium showed no clear difference in response to treatment clinically relevant response as defined by the… compared with antipsychotics (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Acceptability ‐ total dropouts · schizophrenia

It is very uncertain whether lithium changes acceptability of treatment leaving early due to any reason compared with antipsychotics (very low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Response to treatment clinically relevant response as defined by the authors · schizophrenia

Lithium as sole treatment showed no clear difference in response to treatment clinically relevant response as defined by the… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

> 50% reduction in depressive symptoms · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on depressive symptoms at least 50%… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Clinically significant response on manic symptoms at least 50% Bech‐Rafaelsen improvement · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on manic symptoms at least 50%… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on positive symptoms at least 50% MS… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Kidney dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review