Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

551 questions · 579 findings · 72 reviews · Headline outcomes only

No studies found 158 · 27.3%GRADE not reported 44 · 7.6%Very low 173 · 29.9%Low 112 · 19.3%Moderate 66 · 11.4%High 26 · 4.5%

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes hearing: return to normal hearing at 6 to 9 months № of… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes presence/persistence of OME ‐ over 12 months № of participants: 254… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Specific adverse events: haemorrhage · children aged 6 months to 12 years with otitis media with effusion (OME)

Adenoidectomy and bilateral ventilation tubes showed no clear difference in adverse event: haemorrhage № of participants: 791(2 RCTs) compared with bilateral ventilation tubes only (low certainty).

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes hearing: proportion of children with hearing returned to normal (12… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Motor alignment at distance fixation Measured using the PACT at 1 year · people with intermittent exotropia, aged over 6 years

Lateral rectus recession and medial rectus plication showed no clear difference in motor alignment at distance fixation Measured using the PACT at 1 year compared with lateral rectus recession and medial rectus resection (low certainty).

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Motor fusion test · people with intermittent exotropia, aged over 6 years

It is very uncertain whether lateral rectus recession and medial rectus plication changes motor fusion test Measured using the synoptophore and Titmus fly… compared with lateral rectus recession and medial rectus resection (very low certainty).

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Lateral postures vs other postures

Severe perineal tears (3rd degree or higher, as defined by trialists) · fetal malposition in labour

It is very uncertain whether lateral postures changes severe perineal tears (3rd degree or higher, as defined by trialists) compared with other postures (very low certainty).

1 finding from 1 review

Lateral postures vs other postures

Maternal satisfaction (as defined by trialists using standardised tools available) · fetal malposition in labour

Lateral postures showed no clear difference in maternal satisfaction (as defined by trialists using standardised… compared with other postures (low certainty).

1 finding from 1 review

Lateral postures vs other postures

Serious neonatal morbidity (composite outcome defined as death, admission to neonatal intensive care, neonatal encephalopathy, or as defined by trialists) · fetal malposition in labour

It is very uncertain whether lateral postures changes serious neonatal morbidity (composite outcome defined as death,… compared with other postures (very low certainty).

1 finding from 1 review