Findings

What do systematic reviews say?

578 questions · 600 findings · 55 reviews · Headline outcomes only

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No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 100 · 16.7%Low 142 · 23.7%Moderate 116 · 19.3%High 30 · 5%

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Mental state · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Adverse effects: tardive dyskinesia: medium term (13‐25 weeks) as defined in each study · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Cost‐effectiveness · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether ANY INTERMITTENT DRUG TECHNIQUE changes leaving the study early/ loss to compared with PLACEBO (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.97 [1.28, 3.01]
2 studies · 90 participants
Very low

Intermittent use of iron supplements vs any daily iron supplementation

Iron deficiency (as defined by trialists) · adolescent and adult menstruating women

It is very uncertain whether intermittent iron supplementation changes iron deficiency (as defined by the trialists using indicators of… compared with daily iron supplementation (very low certainty).

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
RR 4.3 [0.56, 33.2]
1 study · 198 participants
Very low

Intermittent use of iron supplements vs any daily iron supplementation

Ferritin (µg/L) · adolescent and adult menstruating women

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 988 participants
Low

Intermittent use of iron supplements vs any daily iron supplementation

Iron deficiency anaemia · adolescent and adult menstruating women

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intermittent use of iron supplements vs any daily iron supplementation

All‐cause morbidity · adolescent and adult menstruating women

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intermittent use of iron supplements vs any daily iron supplementation

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation may leads to lower any adverse side effects compared with daily iron supplementation (low certainty).

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
RR 0.41 [0.21, 0.82]
6 studies · 1166 participants
Low

Intermittent use of iron supplements vs any daily iron supplementation

Anaemia · adolescent and adult menstruating women

Intermittent iron supplementation showed no clear difference in anaemia (haemoglobin concentration below a cut‐off defined by the… compared with daily iron supplementation (moderate certainty).

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
RR 1.09 [0.93, 1.29]
8 studies · 1749 participants
Moderate

Intermittent use of iron supplements vs any daily iron supplementation

Haemoglobin (g/dL) · adolescent and adult menstruating women

1 finding from 1 review

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult… 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2127 participants
Low

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Relapse · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Hospital admissions · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Global state: average score: long term (+ 26 weeks) Global Assessment Scale (GAS). Scale from: 0 to 100. · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Mental state · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Adverse effects: tardive dyskinesia: long term (+ 26 weeks) as defined in each study · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Cost‐effectiveness · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether INTERMITTENT (CRISIS INTERVENTION) changes leaving the study early/ loss to compared with MAINTENANCE THERAPY (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.57 [1.23, 2]
1 study · 237 participants
Very low

Intermittent use of iron supplements vs placebo or no intervention

Anaemia · children under 12 years of age

Intermittent use of iron supplements probably leads to lower anaemia (haemoglobin below a cut‐off defined by trialists, taking… compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Intermittent iron supplementation for improving nutrition and development in children under 12 years of age 2011 · Cochrane Headline outcomes only
RR 0.51 [0.37, 0.72]
10 studies · 1824 participants
Moderate

Intermittent use of iron supplements vs placebo or no intervention

Haemoglobin (g/dL) · children under 12 years of age

Intermittent use of iron supplements may leads to higher haemoglobin (g/L) compared with placebo or no intervention (low certainty).

1 finding from 1 review

Intermittent iron supplementation for improving nutrition and development in children under 12 years of age 2011 · Cochrane Headline outcomes only
MD 5.2 [2.51, 7.88]
19 studies · 3032 participants
Low