Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

336 questions · 357 findings · 36 reviews

No studies found 65 · 18.2%GRADE not reported 16 · 4.5%Very low 87 · 24.4%Low 114 · 31.9%Moderate 60 · 16.8%High 15 · 4.2%

Interferon beta‐1a vs placebo

Improvement in disability grade Defined as achievement of a specified degree of improvement · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes improvement in disability grade Defined as achievement of a… compared with placebo (very low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants who completed the study and did not restart IVIg therapy after IVIg withdrawal · people with CIDP

Interferon beta‐1a showed no clear difference in participants who completed the study and did not restart IVIg… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon‐α alone vs standard targeted therapies

QoL · previously untreated patients with mRCC
5 findings from 1 review
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Interferon beta‐1a vs placebo

Change in timed walk at 6 months (%) e.g. 10‐metre or 6‐minute walk test at 6 months ‐ not measured · people with inclusion body myositis

The review found no eligible studies for this question.

1 finding from 1 review