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Evidence found and GRADE certainty

395 questions · 407 findings · 33 reviews · Headline outcomes only

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No studies found 113 · 27.8%GRADE not reported 39 · 9.6%Very low 91 · 22.4%Low 105 · 25.8%Moderate 50 · 12.3%High 9 · 2.2%

Summary of findings: insulin detemir vs Insulin glargin (control)

Injection‐site reaction Rates of patients · patients with type 2 diabetes mellitus

Insulin detemir (intervention) may leads to higher percentage of participants having at least one injection site reaction compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Caesarean section 4 · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes caesarean section 4 compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin injected with a Novolin pen changes macrosomia compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

1 finding from 1 review

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

Caesarean section 4 · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin injected with a Novolin pen changes caesarean section 4 compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs insulin glargine

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

It is very uncertain whether summary of findings: insulin detemir changes severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (very low certainty).

1 finding from 1 review