Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

436 questions · 451 findings · 96 reviews · Headline outcomes only

No studies found 31 · 6.9%GRADE not reported 17 · 3.8%Very low 149 · 33%Low 130 · 28.8%Moderate 103 · 22.8%High 21 · 4.7%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in intraventricular haemorrhage (IVH, all grades) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Periventricular leukomalacia · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in periventricular leukomalacia (PVL) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Chronic lung disease · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in chronic lung disease (CLD) ‐ oxygen supplement at 36 weeks… compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Maternal blood loss of 500 mL or greater · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in maternal blood loss of 500 mL or greater compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Death of baby (up to discharge) · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in death of baby (up to discharge) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Death or neurodevelopmental impairment at age 2 to 3 years · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact may leads to lower death or neurodevelopmental impairment at age 2 to 3 years compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Death of baby (up to discharge) · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping probably leads to lower death of baby (up to discharge) compared with ECC (subgroup analysis by gestation) (moderate certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Death of baby (up to discharge) · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in death of baby (up to discharge) compared with UCM (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Death or neurodevelopmental impairment at age 2 to 3 years · babies born preterm, and their mothers

It is very uncertain whether DCC with immediate neonatal care after cord clamping changes death or neurodevelopmental impairment at age 2 to 3 years compared with UCM (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with UCM (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Intraventricular haemorrhage · babies born preterm, and their mothers

It is very uncertain whether DCC with immediate neonatal care after cord clamping changes intraventricular haemorrhage (IVH, all grades) compared with UCM (very low certainty).

1 finding from 1 review