Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

216 questions · 218 findings · 21 reviews · Heart

No studies found 30 · 13.8%GRADE not reported 1 · 0.5%Very low 49 · 22.5%Low 71 · 32.6%Moderate 48 · 22%High 19 · 8.7%

Statins vs placebo

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Lidocaine vs disopyramide

Adverse events (AEs; adverse drug reaction): cardiac blocks (high‐degree atrioventricular block and bundle) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): cardiac blocks… compared with disopyramide (very low certainty).

1 finding from 1 review

Mindfulness‐based interventions (MBIs) vs non‐active comparators

Clinical CVD events (CVD mortality and non‐fatal MI) · people at high risk of or withcardiovascular disease

It is very uncertain whether mindfulness‐based interventions (MBIs) changes clinical CVD events (CVD mortality and non‐fatal MI) compared with non‐active comparators (very low certainty).

1 finding from 1 review