Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

99 questions · 116 findings · 18 reviews · Gut

No studies found 7 · 6%GRADE not reported 3 · 2.6%Very low 62 · 53.4%Low 25 · 21.6%Moderate 17 · 14.7%High 2 · 1.7%

Risk of postoperative infectious complications: anti‐integrin agents vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications: anti‐integrin agents vs control

Extra‐abdominal infections within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes extra‐abdominal infections within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Incisional infections and wound dehiscence within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes incisional infections and wound dehiscence within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Extra‐abdominal infections within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes extra‐abdominal infections within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

5‐ASA vs control

Infectious complications · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: 5‐ASA changes overall infectious complications within 30 days of surgery compared with control (very low certainty).

3 findings from 1 review

Mesalamine vs sulfasalazine

Clinical remission or improvement · patients with Induction of remission or response in Crohn's disease

It is very uncertain whether mesalamine changes induction of remission (CDAI < 150) or clinical improvement ‐… compared with sulfasalazine (alone or (very low certainty).

2 findings from 1 review

Intervention not reported

Postoperative mortality (within 30 days from surgery) · patients with resectable disease

The intervention leads to higher postoperative mortality (within 30 days from surgery) (high certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Mortality rate Number of deaths (30‐day mortality or in‐hospital mortality) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower mortality rate Number of deaths (30‐day mortality or in‐hospital… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of AAD · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention probably leads to lower incidence of AAD (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention showed no clear difference in adverse events (low certainty).

1 finding from 1 review

Other prokinetics vs domperidone

Adverse events · patients with functional dyspepsia

It is very uncertain whether other prokinetics changes adverse events compared with domperidone 10mg three times a day (very low certainty).

1 finding from 1 review