Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

513 questions · 560 findings · 38 reviews · Headline outcomes only

No studies found 107 · 19.1%GRADE not reported 10 · 1.8%Very low 168 · 30%Low 146 · 26.1%Moderate 107 · 19.1%High 22 · 3.9%

100 mg olorinab 3 times/day vs 25 mg olorinab 3 times/day

At least 30% reduction in pain · people with Crohn's disease

It is very uncertain whether 100 mg olorinab 3 times/day changes pain intensity (30% reduction in weekly AAPS) compared with 25 mg olorinab 3 times/day (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Withdrawals due to adverse events · induction of remission in Crohn's disease

It is very uncertain whether probiotics changes adverse events leading to withdrawal compared with placebo (very low certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain remission · Participants with Crohn's disease in remission

Adalimumab leads to lower failure to maintain clinical remission compared with placebo (high certainty).

2 findings from 1 review

Adalimumab vs placebo

Failure to maintain endoscopic remission · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain endoscopic remission compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs placebo

Withdrawals due to adverse events · Participants with Crohn's disease in remission

Adalimumab probably leads to lower withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain clinical or endoscopic response with prior TNF‐α antagonist exposure · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain clinical or endoscopic response with prior TNF‐α… compared with placebo (moderate certainty).

1 finding from 1 review