Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

470 questions · 477 findings · 110 reviews · Headline outcomes only

No studies found 68 · 14.3%GRADE not reported 41 · 8.6%Very low 143 · 30%Low 133 · 27.9%Moderate 73 · 15.3%High 19 · 4%

Intensive counseling vs usual family planning care

Rate of discontinuation due to all other adverse events · Women of reproductive age seeking to avoid pregnancy

Intensive counseling showed no clear difference in rate of discontinuation due to all other adverse events compared with usual family planning care (low certainty).

1 finding from 1 review

Reminders (+/‐ educational information) vs usual family planning care

Continuation of hormonal contraceptive method · Women of reproductive age seeking to avoid pregnancy

It is very uncertain whether reminders (+/‐ educational information) changes continuation of hormonal contraceptive method compared with usual family planning care (very low certainty).

1 finding from 1 review

Valproate vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether valproate changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Paroxetine vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether paroxetine changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review