Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,432 questions · 1,467 findings · 116 reviews · Headline outcomes only

No studies found 232 · 15.8%GRADE not reported 202 · 13.8%Very low 286 · 19.5%Low 327 · 22.3%Moderate 286 · 19.5%High 134 · 9.1%

Mammography in combination with breast ultrasonography vs mammography alone

False‐positive rate · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher false‐positive rate compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐negative rate · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography probably leads to lower false‐negative rate compared with mammography alone (moderate certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Rate of biopsies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher rate of biopsies compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection in women with dense breasts: cohort studies · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental cancer detection in women with dense breasts: RCT compared with mammography alone (high certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental detection of invasive cancers · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental detection of invasive cancers compared with mammography alone (low certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐positive rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography leads to higher false‐positive rate in women with dense breasts compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐negative rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography probably leads to lower false‐negative rate in women with dense breasts compared with mammography alone (moderate certainty).

1 finding from 1 review