Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

172 questions · 216 findings · 32 reviews · All outcomes

No studies found 24 · 11.1%GRADE not reported 151 · 69.9%Very low 28 · 13%Low 5 · 2.3%Moderate 8 · 3.7%High 0 · 0%

Salvadora persica (miswak) mouthrinse vs Chlorhexidine mouthwash

Patient self-assessment VAS (scale 0 to 10) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) mouthwash changes patient self-assessment VAS (scale 0 to 10) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Patient self-assessment VAS (scale 0 to 10) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) stick changes patient self-assessment VAS (scale 0 to 10) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

Fixed-appliance orthodontic treatment incorporating surgically assisted orthodontics (adjunctive surgical procedure: corticotomy, micro-osteoperforation or interseptal bone reduction) to increase the rate of tooth movement vs Conventional orthodontic appliance treatment

Improvement in occlusion (Peer Assessment Rating (PAR) or other validated scale) · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…

The review found no eligible studies for this question.

1 finding from 1 review

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Aesthetics · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Assessment of the alignment of the lower front teeth using any method or index · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Topical clobetasol propionate 0.025% showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.05%; GRADE not reported.

1 finding from 1 review

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

1% pimecrolimus cream vs Placebo (vehicle cream)

Participant global self-assessment · People with erosive oral lichen planus
1 finding from 1 review
  • One study (Passeron 2007) assessed participant global self-assessment on a 5-point scale: 5/6 participants in the 1% pimecrolimus group rated their improvement as moderate or important versus 1/6 in the placebo group…
    1 study · 12 participants
    GRADE not reported

Radix tripterygium hypoglaucum tablet (THT) vs Tripterygium glucosides tablet (TGT)

Physician Global Assessment (cure of erosive lesions, remarkably effective) · People with erosive oral lichen planus

Radix tripterygium hypoglaucum tablet (THT) showed no clear difference in physician Global Assessment (cure of erosive lesions, remarkably… compared with tripterygium glucosides tablet (TGT); GRADE not reported.

2 findings from 1 review

1% pimecrolimus cream vs Placebo (vehicle cream)

Physician Global Assessment (weighted sums of ulceration, erythema, reticulation, mm2) · People with erosive oral lichen planus

1% pimecrolimus cream showed no clear difference in physician Global Assessment (weighted sums of ulceration, erythema,… compared with placebo (vehicle cream); GRADE not reported.

1 finding from 1 review

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus

Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.

1 finding from 1 review

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Clobetasol-17-propionate 0.025% lipid-loaded microspheres showed no clear difference in physician Global Assessment (Thongprasom score) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

1 finding from 1 review