What do systematic reviews say?

Topical antibiotics vs another topical antibiotic or placebo

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Topical antibiotics vs another topical antibiotic or placebo

The review found no eligible studies for this question.

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics vs another topical antibiotic or placebo

The review found no eligible studies for this question.

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics vs another topical antibiotic or placebo

The review found no eligible studies for this question.

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics vs another topical antibiotic or placebo

The review found no eligible studies for this question.

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics vs another topical antibiotic or placebo

• Antibiotic prophylaxis for corneal abrasion 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 400 participants
  Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  OR 0.94 [0.55, 1.61]
  1 study · 400 participants
  Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs placebo or no treatment

The review found no eligible studies for this question.

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs placebo or no treatment

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Antibiotics vs placebo or no treatment

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.53 [0.4, 0.69]
  Studies not reported
  High

Antibiotics vs placebo or no treatment

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.46 [0.31, 0.69]
  Studies not reported
  High

Antibiotics vs placebo or no treatment

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.11 [0.01, 2.05]
  Studies not reported
  Low

Antibiotics vs placebo or no treatment

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.52 [0.43, 0.63]
  Studies not reported
  Moderate

Antibiotics vs placebo or no treatment

Any antibiotics showed no clear difference in endometritis № of participants: 3813 (2 RCTs) compared with placebo or no treatment (low certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.32 [0.04, 2.64]
  Studies not reported
  Low

Antibiotics vs placebo or no treatment

The review found no eligible studies for this question.

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs placebo or no treatment

Any antibiotics leads to lower serious infectious complications № of participants: 3420 (1 RCT) compared with placebo or no treatment (high certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 0.44 [0.22, 0.89]
  Studies not reported
  High

Antibiotics vs placebo or no treatment

Any antibiotics showed no clear difference in maternal adverse reactions № of participants: 2593 (1 RCT) compared with placebo or no treatment (low certainty).

• Antibiotic prophylaxis for operative vaginal delivery 2020 · Cochrane Headline outcomes only
  RR 2 [0.18, 22.05]
  Studies not reported
  Low